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Clair3-Trio is a variants caller tailored for family trios from nanopore long-reads. Clair3-Trio employs a Trio-to-Trio deep neural network model that allows it to input all trio’s sequencing information and output all trio’s predicted variants within a single model, to perform far better variant calling. We also present MCVLoss, the first loss function that can improve variants calling in trios by leveraging the explicitly encoding of the priors of the Mendelian inheritance in trios. Clair3-Trio showed comprehensive improvement in experiments. It predicted much fewer Mendelian inheritance violation variations than current state-of-the-art methods.

Type Size Name Uploaded Downloads Labels
conda 708.7 MB | linux-64/clair3-trio-0.7-py39hd649744_2.tar.bz2  2 months and 11 days ago 69 main
conda 708.7 MB | linux-64/clair3-trio-0.7-py39h46983ab_1.tar.bz2  8 months and 17 days ago 199 main
conda 708.7 MB | linux-64/clair3-trio-0.7-py39hf5e1c6e_0.tar.bz2  1 year and 7 months ago 1190 main
conda 460.5 kB | linux-64/clair3-trio-0.6-py39h8492097_1.tar.bz2  1 year and 9 months ago 112 main
conda 458.3 kB | linux-64/clair3-trio-0.6-py39hb9dc472_0.tar.bz2  1 year and 10 months ago 1322 main
conda 400.3 kB | linux-64/clair3-trio-0.5-py36hb9dc472_0.tar.bz2  1 year and 10 months ago 1379 main
conda 191.2 kB | linux-64/clair3-trio-0.3-py36hb9dc472_2.tar.bz2  1 year and 11 months ago 1442 main
conda 191.1 kB | linux-64/clair3-trio-0.3-py36hb9dc472_1.tar.bz2  2 years and 5 months ago 459 main
conda 192.4 kB | linux-64/clair3-trio-0.3-py36hb9dc472_0.tar.bz2  2 years and 8 months ago 281 main
conda 187.2 kB | linux-64/clair3-trio-0.2-py36hb9dc472_0.tar.bz2  2 years and 9 months ago 1990 main
conda 437.6 kB | linux-64/clair3-trio-0.1-py36hb9dc472_0.tar.bz2  2 years and 10 months ago 2029 main

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