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Clair3-Trio is a variants caller tailored for family trios from nanopore long-reads. Clair3-Trio employs a Trio-to-Trio deep neural network model that allows it to input all trio’s sequencing information and output all trio’s predicted variants within a single model, to perform far better variant calling. We also present MCVLoss, the first loss function that can improve variants calling in trios by leveraging the explicitly encoding of the priors of the Mendelian inheritance in trios. Clair3-Trio showed comprehensive improvement in experiments. It predicted much fewer Mendelian inheritance violation variations than current state-of-the-art methods.

Type Size Name Uploaded Downloads Labels
conda 708.7 MB | linux-64/clair3-trio-0.7-py39hd649744_2.tar.bz2  3 months and 12 days ago 84 main
conda 708.7 MB | linux-64/clair3-trio-0.7-py39h46983ab_1.tar.bz2  9 months and 19 days ago 214 main
conda 708.7 MB | linux-64/clair3-trio-0.7-py39hf5e1c6e_0.tar.bz2  1 year and 8 months ago 1256 main
conda 460.5 kB | linux-64/clair3-trio-0.6-py39h8492097_1.tar.bz2  1 year and 10 months ago 123 main
conda 458.3 kB | linux-64/clair3-trio-0.6-py39hb9dc472_0.tar.bz2  1 year and 11 months ago 1391 main
conda 400.3 kB | linux-64/clair3-trio-0.5-py36hb9dc472_0.tar.bz2  1 year and 11 months ago 1447 main
conda 191.2 kB | linux-64/clair3-trio-0.3-py36hb9dc472_2.tar.bz2  2 years and 25 days ago 1510 main
conda 191.1 kB | linux-64/clair3-trio-0.3-py36hb9dc472_1.tar.bz2  2 years and 6 months ago 469 main
conda 192.4 kB | linux-64/clair3-trio-0.3-py36hb9dc472_0.tar.bz2  2 years and 9 months ago 291 main
conda 187.2 kB | linux-64/clair3-trio-0.2-py36hb9dc472_0.tar.bz2  2 years and 10 months ago 2059 main
conda 437.6 kB | linux-64/clair3-trio-0.1-py36hb9dc472_0.tar.bz2  2 years and 11 months ago 2097 main

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