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Clair3-Trio is a variants caller tailored for family trios from nanopore long-reads. Clair3-Trio employs a Trio-to-Trio deep neural network model that allows it to input all trio’s sequencing information and output all trio’s predicted variants within a single model, to perform far better variant calling. We also present MCVLoss, the first loss function that can improve variants calling in trios by leveraging the explicitly encoding of the priors of the Mendelian inheritance in trios. Clair3-Trio showed comprehensive improvement in experiments. It predicted much fewer Mendelian inheritance violation variations than current state-of-the-art methods.

Type Size Name Uploaded Downloads Labels
conda 708.7 MB | linux-64/clair3-trio-0.7-py39hd649744_2.tar.bz2  2 months and 22 days ago 77 main
conda 708.7 MB | linux-64/clair3-trio-0.7-py39h46983ab_1.tar.bz2  9 months and 1 day ago 205 main
conda 708.7 MB | linux-64/clair3-trio-0.7-py39hf5e1c6e_0.tar.bz2  1 year and 7 months ago 1218 main
conda 460.5 kB | linux-64/clair3-trio-0.6-py39h8492097_1.tar.bz2  1 year and 9 months ago 117 main
conda 458.3 kB | linux-64/clair3-trio-0.6-py39hb9dc472_0.tar.bz2  1 year and 10 months ago 1352 main
conda 400.3 kB | linux-64/clair3-trio-0.5-py36hb9dc472_0.tar.bz2  1 year and 11 months ago 1409 main
conda 191.2 kB | linux-64/clair3-trio-0.3-py36hb9dc472_2.tar.bz2  2 years and 7 days ago 1471 main
conda 191.1 kB | linux-64/clair3-trio-0.3-py36hb9dc472_1.tar.bz2  2 years and 5 months ago 463 main
conda 192.4 kB | linux-64/clair3-trio-0.3-py36hb9dc472_0.tar.bz2  2 years and 8 months ago 286 main
conda 187.2 kB | linux-64/clair3-trio-0.2-py36hb9dc472_0.tar.bz2  2 years and 9 months ago 2020 main
conda 437.6 kB | linux-64/clair3-trio-0.1-py36hb9dc472_0.tar.bz2  2 years and 10 months ago 2059 main

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