SIRIUS is a java-based software framework for the analysis of LC-MS/MS data of metabolites and other small molecules of biological interest. SIRIUS integrates a collection of our tools, including CSI:FingerID (with COSMIC), ZODIAC and CANOPUS. In particular, both the graphical user interface and the command line version of SIRIUS seamlessly integrate the CSI:FingerID and CANOPUS web services.