pyOptSparse is an object-oriented framework for formulating and solving nonlinear constrained optimization problems in an efficient, reusable, and portable manner. It is a fork of pyOpt that uses sparse matrices throughout the code to more efficiently handle large-scale optimization problems. Interfaces are provided for a number of optimizers -- for the conda package the optimizers ALPSO, CONMIN, IPOPT, NSGA2, PSQP, and SLSQP are supported.