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Provides a computational framework for analyzing mutations in immunoglobulin (Ig) sequences. Includes methods for Bayesian estimation of antigen-driven selection pressure, mutational load quantification, building of somatic hypermutation (SHM) models, and model-dependent distance calculations. Also includes empirically derived models of SHM for both mice and humans. Citations: Gupta and Vander Heiden, et al (2015) <doi:10.1093/bioinformatics/btv359>, Yaari, et al (2012) <doi:10.1093/nar/gks457>, Yaari, et al (2013) <doi:10.3389/fimmu.2013.00358>, Cui, et al (2016) <doi:10.4049/jimmunol.1502263>.

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conda 2.1 MB | noarch/r-shazam-0.2.1-r36h6115d3f_1.tar.bz2  5 years and 27 days ago 2423 main
conda 2.1 MB | noarch/r-shazam-0.2.1-r36h6115d3f_0.tar.bz2  5 years and 3 months ago 257 main

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