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eagle2

Community

The Eagle software estimates haplotype phase either within a genotyped cohort or using a phased reference panel.

Installation

To install this package, run one of the following:

Conda
$conda install bioconda::eagle2

Usage Tracking

2.4.1
1 / 8 versions selected
Downloads (Last 6 months): 0

Description

Eagle2 is now the default phasing method used by the Sanger and Michigan imputation servers and uses a new very fast HMM-based algorithm that improves speed and accuracy over existing methods via two key ideas; a new data structure based on the positional Burrows-Wheeler transform and a rapid search algorithm that explores only the most relevant paths through the HMM. Compared to the Eagle1 algorithm, Eagle2 has similar speed but much greater accuracy at sample sizes <50,000; as such, we have made the Eagle2 algorithm the default option. (The Eagle1 algorithm can be accessed via the --v1 flag.) Eagle v2.3+ supports phasing sequence data with or without a reference and also supports phasing chrX.

About

Summary

The Eagle software estimates haplotype phase either within a genotyped cohort or using a phased reference panel.

Last Updated

Nov 4, 2024 at 13:40

License

GPL-3.0-or-later

Total Downloads

596

Supported Platforms

linux-64
macOS-64