eagle2
The Eagle software estimates haplotype phase either within a genotyped cohort or using a phased reference panel.
The Eagle software estimates haplotype phase either within a genotyped cohort or using a phased reference panel.
To install this package, run one of the following:
Eagle2 is now the default phasing method used by the Sanger and Michigan imputation servers and uses a new very fast HMM-based algorithm that improves speed and accuracy over existing methods via two key ideas; a new data structure based on the positional Burrows-Wheeler transform and a rapid search algorithm that explores only the most relevant paths through the HMM. Compared to the Eagle1 algorithm, Eagle2 has similar speed but much greater accuracy at sample sizes <50,000; as such, we have made the Eagle2 algorithm the default option. (The Eagle1 algorithm can be accessed via the --v1 flag.) Eagle v2.3+ supports phasing sequence data with or without a reference and also supports phasing chrX.
Summary
The Eagle software estimates haplotype phase either within a genotyped cohort or using a phased reference panel.
Last Updated
Nov 4, 2024 at 13:40
License
GPL-3.0-or-later
Total Downloads
596
Supported Platforms