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bioconda / packages / bioconductor-sccb2 1.12.0

CB2 improves power of cell detection in droplet-based single-cell RNA sequencing data

Installers

  • noarch v1.12.0

conda install

To install this package run one of the following:
conda install bioconda::bioconductor-sccb2

Description

scCB2 is an R package implementing CB2 for distinguishing real cells from empty droplets in droplet-based single cell RNA-seq experiments (especially for 10x Chromium). It is based on clustering similar barcodes and calculating Monte-Carlo p-value for each cluster to test against background distribution. This cluster-level test outperforms single-barcode-level tests in dealing with low count barcodes and homogeneous sequencing library, while keeping FDR well controlled.


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