bioconda / packages / bioconductor-multtest 2.44.0

Resampling-based multiple hypothesis testing

Installers

Info: This package contains files in non-standard labels.

conda install

  • linux-64  v2.44.0
  • osx-64  v2.44.0
To install this package with conda run one of the following:
conda install -c bioconda bioconductor-multtest
conda install -c bioconda/label/gcc7 bioconductor-multtest
conda install -c bioconda/label/cf201901 bioconductor-multtest

Description

Non-parametric bootstrap and permutation resampling-based multiple testing procedures (including empirical Bayes methods) for controlling the family-wise error rate (FWER), generalized family-wise error rate (gFWER), tail probability of the proportion of false positives (TPPFP), and false discovery rate (FDR). Several choices of bootstrap-based null distribution are implemented (centered, centered and scaled, quantile-transformed). Single-step and step-wise methods are available. Tests based on a variety of t- and F-statistics (including t-statistics based on regression parameters from linear and survival models as well as those based on correlation parameters) are included. When probing hypotheses with t-statistics, users may also select a potentially faster null distribution which is multivariate normal with mean zero and variance covariance matrix derived from the vector influence function. Results are reported in terms of adjusted p-values, confidence regions and test statistic cutoffs. The procedures are directly applicable to identifying differentially expressed genes in DNA microarray experiments.

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