R generic interface to Hi-C contact matrices in .(m)cool, .hic or HiC-Pro derived formats, as well as other Hi-C processed file formats. Contact matrices can be partially parsed using a random access method, allowing a memory-efficient representation of Hi-C data in R. The HiCExperiment class stores the Hi-C contacts parsed from local contact matrix files. HiCExperiment instances can be further investigated in R using the HiContacts analysis package.