bioconda / packages / bioconductor-genextender 1.20.0

Optimized Functional Annotation Of ChIP-seq Data

Installers

Info: This package contains files in non-standard labels.

conda install

  • linux-64  v1.20.0
  • osx-64  v1.20.0
To install this package with conda run one of the following:
conda install -c bioconda bioconductor-genextender
conda install -c bioconda/label/gcc7 bioconductor-genextender

Description

geneXtendeR optimizes the functional annotation of ChIP-seq peaks by exploring relative differences in annotating ChIP-seq peak sets to variable-length gene bodies. In contrast to prior techniques, geneXtendeR considers peak annotations beyond just the closest gene, allowing users to see peak summary statistics for the first-closest gene, second-closest gene, ..., n-closest gene whilst ranking the output according to biologically relevant events and iteratively comparing the fidelity of peak-to-gene overlap across a user-defined range of upstream and downstream extensions on the original boundaries of each gene's coordinates. Since different ChIP-seq peak callers produce different differentially enriched peaks with a large variance in peak length distribution and total peak count, annotating peak lists with their nearest genes can often be a noisy process. As such, the goal of geneXtendeR is to robustly link differentially enriched peaks with their respective genes, thereby aiding experimental follow-up and validation in designing primers for a set of prospective gene candidates during qPCR.


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