bioconda / packages / bioconductor-dyebias 1.48.0

The GASSCO method for correcting for slide-dependent gene-specific dye bias

Installers

Info: This package contains files in non-standard labels.

conda install

  • linux-64  v1.40.0
  • osx-64  v1.40.0
  • noarch  v1.48.0
To install this package with conda run one of the following:
conda install -c bioconda bioconductor-dyebias
conda install -c bioconda/label/gcc7 bioconductor-dyebias
conda install -c bioconda/label/cf201901 bioconductor-dyebias

Description

Many two-colour hybridizations suffer from a dye bias that is both gene-specific and slide-specific. The former depends on the content of the nucleotide used for labeling; the latter depends on the labeling percentage. The slide-dependency was hitherto not recognized, and made addressing the artefact impossible. Given a reasonable number of dye-swapped pairs of hybridizations, or of same vs. same hybridizations, both the gene- and slide-biases can be estimated and corrected using the GASSCO method (Margaritis et al., Mol. Sys. Biol. 5:266 (2009), doi:10.1038/msb.2009.21)

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