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Implements the method described in "Network-based analysis of omics data: The LEAN method" [Gwinner Boulday (2016) <DOI:10.1093/bioinformatics/btw676>] Given a protein interaction network and a list of p-values describing a measure of interest (as e.g. differential gene expression) this method computes an enrichment p-value for the protein neighborhood of each gene and compares it to a background distribution of randomly drawn p-values. The resulting scores are corrected for multiple testing and significant hits are returned in tabular format.

Type Size Name Uploaded Downloads Labels
conda 3.0 MB | noarch/r-leanr-1.4.9-r43h142f84f_0.tar.bz2  10 months and 3 days ago 17 main
conda 3.0 MB | noarch/r-leanr-1.4.9-r42h142f84f_0.tar.bz2  2 years and 4 months ago 47 main
conda 3.0 MB | noarch/r-leanr-1.4.9-r36h6115d3f_0.tar.bz2  4 years and 8 months ago 117 main

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