Constrained Coding Regions (CCRs): https://www.nature.com/articles/s41588-018-0294-6. Regions of human specific coding constraint presumably under strong purifying selection. Constraint is based on the lack of variation within the gnomAD dataset calibrated by the size and CpG content of the region. Regional Constraint is broken up into Autosomes and the X-Chromosome. Chromosomes have been remapped from Ensembl GRCh37 to UCSC hg19.
