*LiftOver* Constrained Coding Regions (CCRs): https://www.nature.com/articles/s41588-018-0294-6. Regions of human specific coding constraint presumably under strong purifying selection. Constraint is based on the lack of variation within the gnomAD dataset calibrated by the size and CpG content of the region. Regional Constraint is broken up into Autosomes and the X-Chromosome. Chromosome coordinates and CCR regions are lifted over from GRCh37 to GRCh38 using the Crossmap algorithm. Any unmapped regions are removed. Any region split into multiple regions are combined. (NOTE: The genomic coordinates have been remapped, but there has been no QC on the CCR percentiles preservation. It is yet to be determined if the CCR percentiles have been completely preserved during the liftover, but it can be assumed they should be similar based on the little to no change in region sizes.)
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