Linear Mixed effect Model Splines ('lmms') implements linear mixed effect model splines for modelling and differential expression for highly dimensional data sets: investNoise() for quality control and filterNoise() for removing non-informative trajectories; lmmSpline() to model time course expression profiles and lmmsDE() performs differential expression analysis to identify differential expression between groups, time and/or group x time interaction.
copied from cf-staging / r-lmms