StrainDesign is a COBRApy-based package for the computational design of metabolic networks. It provides standard and advanced tools for the analysis and redesign of biological networks, including minimal cut sets, OptKnock, RobustKnock and OptCouple, built on a common mixed-integer linear programming core. Computations can be run with GLPK, SCIP, CPLEX or Gurobi.

The conda package is named straindesign-cobra to avoid a clash with the unrelated straindesign package on bioconda; the PyPI project and the Python import name are straindesign.