The Python binding pyAMReX bridges the compute in AMReX block-structured codes and data science: it provides zero-copy application GPU data access for AI/ML, in situ analysis, application coupling and enables rapid, massively parallel prototyping. pyAMReX enhances the Block-Structured AMR Software Framework AMReX and its applications. AMReX is a software framework containing all the functionality to write massively parallel, block-structured adaptive mesh refinement (AMR) applications.