SPOTPY is a Python framework that enables the use of Computational optimization techniques for calibration, uncertainty and sensitivity analysis techniques of almost every (environmental-) model. The package is published in the open source journal PLoS One:

Houska, T., Kraft, P., Chamorro-Chavez, A. and Breuer, L.: SPOTting Model Parameters Using a Ready-Made Python Package, PLoS ONE, 10(12), e0145180, doi:10.1371/journal.pone.0145180, 2015.