Trim Galore v2 is a Rust rewrite of the original Perl Trim Galore. Single static binary, no Python/Perl/Cutadapt/Java/igzip/pigz dependencies. Drop-in compatible with v0.6.x scripts and pipelines (same CLI, same output filenames, same report format) with adapter auto-detection (Illumina, Nextera, Small RNA, BGI/DNBSEQ), poly-G/poly-A trimming, paired-end single-pass processing, RRBS support, and bundled FastQC integration via fastqc-rust.