bioconductor-garfield
GWAS Analysis of Regulatory or Functional Information Enrichment with LD correction
GWAS Analysis of Regulatory or Functional Information Enrichment with LD correction
To install this package, run one of the following:
GARFIELD is a non-parametric functional enrichment analysis approach described in the paper GARFIELD: GWAS analysis of regulatory or functional information enrichment with LD correction. Briefly, it is a method that leverages GWAS findings with regulatory or functional annotations (primarily from ENCODE and Roadmap epigenomics data) to find features relevant to a phenotype of interest. It performs greedy pruning of GWAS SNPs (LD r2 > 0.1) and then annotates them based on functional information overlap. Next, it quantifies Fold Enrichment (FE) at various GWAS significance cutoffs and assesses them by permutation testing, while matching for minor allele frequency, distance to nearest transcription start site and number of LD proxies (r2 > 0.8).
Summary
GWAS Analysis of Regulatory or Functional Information Enrichment with LD correction
Last Updated
Dec 14, 2024 at 14:45
License
GPL-3
Total Downloads
34.1K
Supported Platforms