hyperbox-brain is a Python open source toolbox implementing hyperbox-based machine learning algorithms built on top of scikit-learn and is distributed under the GPL-3.0 license. The project was started in 2018 by Prof. Bogdan Gabrys and Dr. Thanh Tung Khuat at the Complex Adaptive Systems Lab - The University of Technology Sydney. This project is a core module aiming to the formulation of explainable lifelong learning systems in near future.