TopHat is a fast splice junction mapper for RNA-Seq reads.
https://ccb.jhu.edu/software/tophat/index.shtml
TopHat is a fast splice junction mapper for RNA-Seq reads. It aligns RNA-Seq reads to mammalian-sized genomes using the ultra high-throughput short read aligner Bowtie, and then analyzes the mapping results to identify splice junctions between exons.