polars-bio is a Python library for genomics built on top of Polars, Apache Arrow and Apache DataFusion. It provides a DataFrame API for genomics data and is designed to be fast, memory efficient and easy to use.

Key features: - Popular genomic interval operations with a DataFrame API - SQL-powered querying of bioinformatics data - Native parallel engine powered by Apache DataFusion - Out-of-core / streaming processing - Reading from cloud storage - Zero-copy data exchange with Apache Arrow - Support for VCF, BAM, CRAM, SAM, FASTQ, FASTA, BED, GFF, GTF and BigWig/BigBed