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bioconda / packages / bioconductor-crisprscore 1.6.0

On-Target and Off-Target Scoring Algorithms for CRISPR gRNAs

Installers

  • noarch v1.6.0

conda install

To install this package run one of the following:
conda install bioconda::bioconductor-crisprscore

Description

Provides R wrappers of several on-target and off-target scoring methods for CRISPR guide RNAs (gRNAs). The following nucleases are supported: SpCas9, AsCas12a, enAsCas12a, and RfxCas13d (CasRx). The available on-target cutting efficiency scoring methods are RuleSet1, Azimuth, DeepHF, DeepCpf1, enPAM+GB, and CRISPRscan. Both the CFD and MIT scoring methods are available for off-target specificity prediction. The package also provides a Lindel-derived score to predict the probability of a gRNA to produce indels inducing a frameshift for the Cas9 nuclease. Note that DeepHF, DeepCpf1 and enPAM+GB are not available on Windows machines.


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